# Amber14sb and OPC water

**URL:** <https://gromacs.bioexcel.eu/t/amber14sb-and-opc-water/2980>\
**Category:** User discussions\
**Created:** [October 18, 2021, 3:27pm UTC](https://gromacs.bioexcel.eu/t/amber14sb-and-opc-water/2980 "2021-10-18T15:27:44Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![XavierB](https://avatars.discourse-cdn.com/v4/letter/x/b19c9b/32.png) [@XavierB](https://gromacs.bioexcel.eu/u/XavierB)\
**Post date:** [October 18, 2021, 3:27pm UTC](https://gromacs.bioexcel.eu/t/amber14sb-and-opc-water/2980/1 "2021-10-18T15:27:44Z")

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GROMACS version: 2021.2  
GROMACS modification: Yes Added Amber14sb FF

Hi,  
This is probably a naive question, but how can we run MD simulations with OPC water model with the Amber14sb FF ?  
Maybe is it better to stick with TIP4PEw or TIP5P water model for protein/ligand simulations.

Thank you for your advices.

Best  
Xavier