Can GROMACS be used to simulate a collection of several small organic molecules?

GROMACS version: most recent
GROMACS modification: Yes/No
I’m thinking about learning to use GROMACS but first I want to make sure it’s possible to use it for my goals. Can GROMACS be used to simulate a collection of several small organic molecules? For example, a droplet containing 50 cholesterol molecules in liquid state, in a box of vacuum? I can only find tutorials for one organic molecule, solvated.

Which force field would you recommend? Ideally I hope to use MMFF94 but I don’t think files for the MMFF94 force field are available online.

Thank you,
Michael Bijan Afghani

Any condensed-phase system that can be parameterized by a point-charge force field would work.

The main issue here is scientific: cholesterol is a solid up until about 150 °C, well above room temperature, so you’ll need to look for force fields that have been parameterized in a way that will still work at that high temp. How suitable these are is not a decision that others could make on your behalf.

Giacomo