# Can not read file topol.tpr,

**URL:** <https://gromacs.bioexcel.eu/t/can-not-read-file-topol-tpr/10646>\
**Category:** User discussions\
**Created:** [November 27, 2024, 6:54am UTC](https://gromacs.bioexcel.eu/t/can-not-read-file-topol-tpr/10646 "2024-11-27T06:54:39Z")\
**Posts on this page:** 1\
**Page:** 1

<div class="post-metadata">

**Author:** ![mnmnm](https://avatars.discourse-cdn.com/v4/letter/m/cab0a1/32.png) [@mnmnm](https://gromacs.bioexcel.eu/u/mnmnm)\
**Post date:** [November 27, 2024, 6:54am UTC](https://gromacs.bioexcel.eu/t/can-not-read-file-topol-tpr/10646/1 "2024-11-27T06:54:39Z")

</div>

GROMACS version:2024.4  
GROMACS modification: Yes/No  
When running the last step of MD step：gmx mdrun -v -deffnm md\_0\_100  
the following error occurred：  
Command line:  
gmx mdrun -s topol.tpr -deffnm md\_0\_100

Back Off! I just backed up md\_0\_100.log to ./#md\_0\_100.log.1#

* * *

Program: gmx mdrun, version 2024.4-Homebrew  
Source file: src/gromacs/fileio/tpxio.cpp (line 2808)

Fatal error:  
Can not read file topol.tpr,  
this file is from a GROMACS version which is older than 2.0  
Make a new one with grompp or use a gro or pdb file, if possible

What should I do?