# Combining DES-Amber and prmBSC1 force field parameters

**URL:** <https://gromacs.bioexcel.eu/t/combining-des-amber-and-prmbsc1-force-field-parameters/1577>\
**Category:** User discussions\
**Created:** [February 11, 2021, 2:30pm UTC](https://gromacs.bioexcel.eu/t/combining-des-amber-and-prmbsc1-force-field-parameters/1577 "2021-02-11T14:30:24Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![rcrehuet](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/rcrehuet/32/340_2.png) [@rcrehuet](https://gromacs.bioexcel.eu/u/rcrehuet)\
**Post date:** [February 11, 2021, 2:30pm UTC](https://gromacs.bioexcel.eu/t/combining-des-amber-and-prmbsc1-force-field-parameters/1577/1 "2021-02-11T14:30:24Z")

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GROMACS version:2020  
GROMACS modification: No

Hi all,  
We would like to simulate a protein-DNA system using the DES-Amber FF for the protein and the prmBSC1 for the DNA. This is because DES-Amber does not provide DNA parameters.  
Does anybody have experience combining these two FF? They are both from the Amber family. prmBSC1 uses a99SB for proteins, and DES-Amber is based on a99SB, so I think they should be compatible, but I would like to see if somebody has already tested them?  
Thanks,  
Ramon