# CP2K2023.2/GROMACS2024.4 interface + Colvars behaviour

**URL:** <https://gromacs.bioexcel.eu/t/cp2k2023-2-gromacs2024-4-interface-colvars-behaviour/10819>\
**Category:** User discussions\
**Tags:** qm-mm, colvars\
**Created:** [December 15, 2024, 3:30pm UTC](https://gromacs.bioexcel.eu/t/cp2k2023-2-gromacs2024-4-interface-colvars-behaviour/10819 "2024-12-15T15:30:12Z")\
**Posts on this page:** 1\
**Page:** 1

<div class="post-metadata">

**Author:** ![Matte\_o\_rlandi](https://avatars.discourse-cdn.com/v4/letter/m/e47774/32.png) [@Matte\_o\_rlandi](https://gromacs.bioexcel.eu/u/Matte_o_rlandi)\
**Post date:** [December 15, 2024, 3:30pm UTC](https://gromacs.bioexcel.eu/t/cp2k2023-2-gromacs2024-4-interface-colvars-behaviour/10819/1 "2024-12-15T15:30:12Z")

</div>

GROMACS version: 2024.4  
GROMACS modification: Yes/No CP2K 2023.2 interface  
Good evening, I have compiled with success the interface between GROMACS and CP2K and it works fine for standard QM/MM MD simulations (I verified it through benchmarks). I need to use metadynamics for further investigations, i was wondering if Colvars (the versione that now comes natively with GROMACS) would work even on the GROMACS/CP2K interface instead that on GROMACS alone or should i use PLUMED (interfaced with GROMACS)? (THE QM subsystem only will be subjected to methadynamics).