# DNA ending effect

**URL:** <https://gromacs.bioexcel.eu/t/dna-ending-effect/3812>\
**Category:** User discussions\
**Created:** [March 9, 2022, 3:54pm UTC](https://gromacs.bioexcel.eu/t/dna-ending-effect/3812 "2022-03-09T15:54:29Z")\
**Posts on this page:** 1\
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**Author:** ![genie](https://avatars.discourse-cdn.com/v4/letter/g/dfb087/32.png) [@genie](https://gromacs.bioexcel.eu/u/genie)\
**Post date:** [March 15, 2022, 8:21pm UTC](https://gromacs.bioexcel.eu/t/dna-ending-effect/3812/12 "2022-03-15T20:21:44Z")

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Another approach is using the “pull” distance constraints between terminal bases. In this case, we can use standard topologies.  
We discussed this problem earlier: [Constraining terminal basepairs in DNA](https://gromacs.bioexcel.eu/t/constraining-terminal-basepairs-in-dna/2549)

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