# Energy minimization problem

**URL:** <https://gromacs.bioexcel.eu/t/energy-minimization-problem/11653>\
**Category:** User discussions\
**Created:** [March 1, 2025, 2:50am UTC](https://gromacs.bioexcel.eu/t/energy-minimization-problem/11653 "2025-03-01T02:50:40Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![XiaoDingdang](https://avatars.discourse-cdn.com/v4/letter/x/a9a28c/32.png) [@XiaoDingdang](https://gromacs.bioexcel.eu/u/XiaoDingdang)\
**Post date:** [March 1, 2025, 2:50am UTC](https://gromacs.bioexcel.eu/t/energy-minimization-problem/11653/1 "2025-03-01T02:50:40Z")

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GROMACS version:  
GROMACS modification: Yes/No  
Here post your question  
This is the problem I encountered：  
WARNING: Listed nonbonded interaction between particles 2637 and 2652  
at distance 4.210 which is larger than the table limit 2.000 nm.

This is likely either a 1,4 interaction, or a listed interaction inside  
a smaller molecule you are decoupling during a free energy calculation.  
Since interactions at distances beyond the table cannot be computed,  
they are skipped until they are inside the table limit again. You will  
only see this message once, even if it occurs for several interactions.

IMPORTANT: This should not happen in a stable simulation, so there is  
probably something wrong with your system. Only change the table-extension  
distance in the mdp file if you are really sure that is the reason.

I don’t know where the problem is.

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**Author:** ![H.Mosaddeghi](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/h.mosaddeghi/32/4066_2.png) [@H.Mosaddeghi](https://gromacs.bioexcel.eu/u/H.Mosaddeghi)\
**Post date:** [March 1, 2025, 5:55am UTC](https://gromacs.bioexcel.eu/t/energy-minimization-problem/11653/2 "2025-03-01T05:55:46Z")

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> [@XiaoDingdang](#):
>
> WARNING: Listed nonbonded interaction between particles 2637 and 2652  
> at distance 4.210 which is larger than the table limit 2.000 nm.
> 
> This is likely either a 1,4 interaction, or a listed interaction inside  
> a smaller molecule you are decoupling during a free energy calculation.  
> Since interactions at distances beyond the table cannot be computed,  
> they are skipped until they are inside the table limit again. You will  
> only see this message once, even if it occurs for several interactions

please check initial structure. or send your file to telegram ID: @gromacsinfo