# ERROR: Unknown left-hand XXXX in parameter file

**URL:** <https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154>\
**Category:** User discussions\
**Created:** [May 18, 2020, 2:17pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154 "2020-05-18T14:17:51Z")\
**Posts on this page:** 5\
**Page:** 1

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**Author:** ![mjsubach](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/mjsubach/32/387_2.png) [@mjsubach](https://gromacs.bioexcel.eu/u/mjsubach)\
**Post date:** [May 18, 2020, 2:17pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154/1 "2020-05-18T14:17:51Z")

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Hello I am completing Tutorial 1, Step Six: Equilibration and input:

gmx grompp -f nvt.mdp -c em.gro -r em.gro -p topol.top -o nvt.tpr

and received the error:

WARNING 1 [file nvt.mdp, line 52]:  
Unknown left-hand ‘\outl0\strokewidth0 \strokec2 title’ in parameter file

Prior to my input I created the .mdp textedit file below:

title = OPLS Lysozyme NVT equilibration  
define = -DPOSRES ; position restrain the protein  
; Run parameters  
integrator = md ; leap-frog integrator  
nsteps = 50000 ; 2 \* 50000 = 100 ps  
dt = 0.002 ; 2 fs  
; Output control  
nstxout = 500 ; save coordinates every 1.0 ps  
nstvout = 500 ; save velocities every 1.0 ps  
nstenergy = 500 ; save energies every 1.0 ps  
nstlog = 500 ; update log file every 1.0 ps  
; Bond parameters  
continuation = no ; first dynamics run  
constraint\_algorithm = lincs ; holonomic constraints  
constraints = h-bonds ; bonds involving H are constrained  
lincs\_iter = 1 ; accuracy of LINCS  
lincs\_order = 4 ; also related to accuracy  
; Nonbonded settings  
cutoff-scheme = Verlet ; Buffered neighbor searching  
ns\_type = grid ; search neighboring grid cells  
nstlist = 10 ; 20 fs, largely irrelevant with Verlet  
rcoulomb = 1.0 ; short-range electrostatic cutoff (in nm)  
rvdw = 1.0 ; short-range van der Waals cutoff (in nm)  
DispCorr = EnerPres ; account for cut-off vdW scheme  
; Electrostatics  
coulombtype = PME ; Particle Mesh Ewald for long-range electrostatics  
pme\_order = 4 ; cubic interpolation  
fourierspacing = 0.16 ; grid spacing for FFT  
; Temperature coupling is on  
tcoupl = V-rescale ; modified Berendsen thermostat  
tc-grps = Protein Non-Protein ; two coupling groups - more accurate  
tau\_t = 0.1 0.1 ; time constant, in ps  
ref\_t = 300 300 ; reference temperature, one for each group, in K  
; Pressure coupling is off  
pcoupl = no ; no pressure coupling in NVT  
; Periodic boundary conditions  
pbc = xyz ; 3-D PBC  
; Velocity generation  
gen\_vel = yes ; assign velocities from Maxwell distribution  
gen\_temp = 300 ; temperature for Maxwell distribution  
gen\_seed = -1 ; generate a random seed

The GROMACS error website recommended:

### Unknown left-hand XXXX in parameter file

[grompp] has found an unknown term in the [.mdp file](http://www.gromacs.org/Documentation/File_Formats/.mdp_File) fed to it. You should check the spelling of XXXX and look for typographical errors. Be aware that quite a few run parameters changed between GROMACS 3.x and GROMACS 4.x and the output from [grompp](http://www.gromacs.org/Documentation/Gromacs_Utilities/grompp) will sometimes offer helpful commentary about these situations.

Can somebody please assist me with what is wrong with my mdp file input into textedit?  
I am using GROMACS: gmx grompp, version 2019.6

Thanks:)  
Joel  
mjsubach@ncsu.edu

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**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\
**Post date:** [May 18, 2020, 2:29pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154/2 "2020-05-18T14:29:37Z")

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The textedit program is a rich-text editor and will embed formatting characters into your files. Do not use word processing software or rich-text editors when dealing with plain-text simulation input/output files. You will break their format. Only use plain-text editors.

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**Author:** ![mjsubach](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/mjsubach/32/387_2.png) [@mjsubach](https://gromacs.bioexcel.eu/u/mjsubach)\
**Post date:** [May 18, 2020, 2:43pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154/3 "2020-05-18T14:43:51Z")

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Hell jalemkul and thank you for your kind update and I used this same TextEdit (Version 1.12 (329)) for the same tutorial Step-4 Add Ions and did not have this problem, with you now knowing this would you still recommend a different TextEdit?

Kind Regards,  
Joel

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**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\
**Post date:** [May 18, 2020, 3:00pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154/4 "2020-05-18T15:00:32Z")

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You shouldn’t have be using a text editor to make any changes to files. Maybe you saved before exiting when viewing one file but not another. But the advice remains - you cannot use a rich-text editor to manipulate any files that GROMACS reads. They will all break in the same way.

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**Author:** ![mjsubach](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/mjsubach/32/387_2.png) [@mjsubach](https://gromacs.bioexcel.eu/u/mjsubach)\
**Post date:** [May 18, 2020, 3:25pm UTC](https://gromacs.bioexcel.eu/t/error-unknown-left-hand-xxxx-in-parameter-file/154/5 "2020-05-18T15:25:01Z")

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Hello and thanks a bunch for your kind update, its working now:)
