# Fast pulling ligand

**URL:** <https://gromacs.bioexcel.eu/t/fast-pulling-ligand/3110>\
**Category:** User discussions\
**Tags:** free-energy\
**Created:** [November 9, 2021, 12:54pm UTC](https://gromacs.bioexcel.eu/t/fast-pulling-ligand/3110 "2021-11-09T12:54:04Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![himan176122114](https://avatars.discourse-cdn.com/v4/letter/h/e5b9ba/32.png) [@himan176122114](https://gromacs.bioexcel.eu/u/himan176122114)\
**Post date:** [November 9, 2021, 12:54pm UTC](https://gromacs.bioexcel.eu/t/fast-pulling-ligand/3110/1 "2021-11-09T12:54:04Z")

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Can anyone provide me with how to proceed with the fast pulling ligand (FPL) method in Gromacs? What is its difference with Umbrella Sampling?

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**Author:** ![scinikhil](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/scinikhil/32/3483_2.png) [@scinikhil](https://gromacs.bioexcel.eu/u/scinikhil)\
**Post date:** [November 9, 2021, 7:51pm UTC](https://gromacs.bioexcel.eu/t/fast-pulling-ligand/3110/2 "2021-11-09T19:51:26Z")

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> [@himan176122114](#):
>
> fast pulling ligand (FPL) method in Gromacs

Where did you seen such methods? can you provide any link