# Fatal error: reading tpx file (step5\_294.tpr) version 122 with version 119 program

**URL:** <https://gromacs.bioexcel.eu/t/fatal-error-reading-tpx-file-step5-294-tpr-version-122-with-version-119-program/3485>\
**Category:** User discussions\
**Created:** [January 16, 2022, 6:23am UTC](https://gromacs.bioexcel.eu/t/fatal-error-reading-tpx-file-step5-294-tpr-version-122-with-version-119-program/3485 "2022-01-16T06:23:29Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![veerubiotech](https://avatars.discourse-cdn.com/v4/letter/v/e480ec/32.png) [@veerubiotech](https://gromacs.bioexcel.eu/u/veerubiotech)\
**Post date:** [January 16, 2022, 6:23am UTC](https://gromacs.bioexcel.eu/t/fatal-error-reading-tpx-file-step5-294-tpr-version-122-with-version-119-program/3485/1 "2022-01-16T06:23:29Z")

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GROMACS version:2021.2/2020.6  
GROMACS modification: Yes  
Dear Gromacs user,  
i have genrated input files using Charm-gui website. I have gromacs version 2021.2 in my local computer. I ran simulation in this computer for 293 steps (293 ns). Later, i transfred the data to hpc which has gromacs version 2020.6. Obviously, there is .tpr version mismatch and i got the above error.  
my question is, can i run just step 1 in hpc to generate the .tpr? Then rename it to step5\_294.tpr and continue simulation. will it intrupt the progress of simulation at step 294?

Thank you

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**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\
**Post date:** [January 16, 2022, 1:55pm UTC](https://gromacs.bioexcel.eu/t/fatal-error-reading-tpx-file-step5-294-tpr-version-122-with-version-119-program/3485/2 "2022-01-16T13:55:38Z")

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You could regenerate a `.tpr` file but it is generally strongly discouraged to switch between major versions of the software midway in a simulation. It is a reproducibility issue. Use a consistent version.