# Forcefield recommendations for protein-ligand system

**URL:** <https://gromacs.bioexcel.eu/t/forcefield-recommendations-for-protein-ligand-system/7689>\
**Category:** User discussions\
**Tags:** forcefield, analysis-tools\
**Created:** [November 21, 2023, 4:44pm UTC](https://gromacs.bioexcel.eu/t/forcefield-recommendations-for-protein-ligand-system/7689 "2023-11-21T16:44:27Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Panuwid](https://avatars.discourse-cdn.com/v4/letter/p/dc4da7/32.png) [@Panuwid](https://gromacs.bioexcel.eu/u/Panuwid)\
**Post date:** [November 21, 2023, 4:44pm UTC](https://gromacs.bioexcel.eu/t/forcefield-recommendations-for-protein-ligand-system/7689/1 "2023-11-21T16:44:27Z")

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GROMACS version:2023.2-Homebrew  
GROMACS modification: Yes/No  
Here post your question  
I am studying a small protein and a small molecule . I have found that there are many forcefields that can be used for protein-ligand studies, but I am not sure which one is the best fit for my research.  
Therefore, I would like to ask for your advice on the forcefield that is most suitable for my study, considering the following factors:

- Accuracy of the forcefield
- Speed of the simulation

I would be grateful for any advice you can provide.

Thank you for your time and consideration.

Sincerely,  
Panuwid