# gmx\_MMPPBSA analysis

**URL:** <https://gromacs.bioexcel.eu/t/gmx-mmppbsa-analysis/8131>\
**Category:** User discussions\
**Created:** [January 24, 2024, 8:59pm UTC](https://gromacs.bioexcel.eu/t/gmx-mmppbsa-analysis/8131 "2024-01-24T20:59:15Z")\
**Posts on this page:** 1\
**Showing post:** 2

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**Author:** ![MagnusL](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/magnusl/32/2380_2.png) [@MagnusL](https://gromacs.bioexcel.eu/u/MagnusL)\
**Post date:** [January 25, 2024, 8:02am UTC](https://gromacs.bioexcel.eu/t/gmx-mmppbsa-analysis/8131/2 "2024-01-25T08:02:24Z")

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As I just replied in another thread, [G\_mmpbsa analysis - #2 by MagnusL](https://gromacs.bioexcel.eu/t/g-mmpbsa-analysis/8125/2), there are not many gmx\_mmpbsa experts here.

I haven’t used the gmx\_mmpbsa tool at all myself, but in general, when you analyse `delta G` you always need to know what you are comparing to. If not having a specific reference state, it is common to set the lowest `delta G` to 0. You could then consider `delta G` to be `delta delta G` relative to the most favourable configuration. However, if many frames have exactly `delta G` 0, that is suspicious.

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