# GROMACS 2023.4 on RTX5080

**URL:** <https://gromacs.bioexcel.eu/t/gromacs-2023-4-on-rtx5080/12755>\
**Category:** User discussions\
**Created:** [October 10, 2025, 3:02pm UTC](https://gromacs.bioexcel.eu/t/gromacs-2023-4-on-rtx5080/12755 "2025-10-10T15:02:00Z")\
**Posts on this page:** 1\
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**Author:** ![al42and](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/al42and/32/1393_2.png) [@al42and](https://gromacs.bioexcel.eu/u/al42and)\
**Post date:** [October 10, 2025, 5:36pm UTC](https://gromacs.bioexcel.eu/t/gromacs-2023-4-on-rtx5080/12755/2 "2025-10-10T17:36:28Z")

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Hi,

Forward compatibility with new architectures has indeed been broken in GROMACS 2022-2024.6, see the [release note](https://manual.gromacs.org/current/release-notes/2024/2024.6.html#fix-cuda-ptx-generation-for-new-architectures).

Using `-DGMX_CUDA_TARGET_SM=120` should help: you will compile the code specifically for your GPU.

If that fails (there could be issues, haven’t tested), `-DGMX_CUDA_TARGET_COMPUTE=80` is a more gentle fix: it will compile the code for the old architecture but in a forward-compatible way (how it should have worked if not for that bug).

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