# Gromacs / g\_mmpbsa query - can I use Gromacs 2019 for MD Sim, and Gromacs 4.5.1 for MMPBSA? **URL:** \ **Category:** User discussions\ **Created:** [April 7, 2021, 7:34am UTC](https://gromacs.bioexcel.eu/t/gromacs-g-mmpbsa-query-can-i-use-gromacs-2019-for-md-sim-and-gromacs-4-5-1-for-mmpbsa/1911 "2021-04-07T07:34:41Z")\ **Posts on this page:** 2\ **Page:** 1
**Author:** ![DJP](https://avatars.discourse-cdn.com/v4/letter/d/bbe5ce/32.png) [@DJP](https://gromacs.bioexcel.eu/u/DJP)\ **Post date:** [April 7, 2021, 7:34am UTC](https://gromacs.bioexcel.eu/t/gromacs-g-mmpbsa-query-can-i-use-gromacs-2019-for-md-sim-and-gromacs-4-5-1-for-mmpbsa/1911/1 "2021-04-07T07:34:41Z")
GROMACS version: 2019.4 GROMACS modification: No Hello everyone As you all know, installing g\_mmpbsa for recent GROMACS versions is quite difficult ( I have not been able to do it yet). I wanted to ask whether it was acceptable to perform the MD Sim in Gromacs 2019/2020 and later on, use g\_mmpbsa with an earlier compatiable Gromacs versions such as 4.5.1. Will it produce reliable results? NOTE: I am generating a Gromacs 4.5.1 compatible .tpr file using “grompp” command for use with g\_mmpbsa. Does that help in making the calculations reliable? Kindly advise Regards Debojyoti ---
**Author:** ![liuyujie714](https://avatars.discourse-cdn.com/v4/letter/l/73ab20/32.png) [@liuyujie714](https://gromacs.bioexcel.eu/u/liuyujie714)\ **Post date:** [April 11, 2021, 2:51am UTC](https://gromacs.bioexcel.eu/t/gromacs-g-mmpbsa-query-can-i-use-gromacs-2019-for-md-sim-and-gromacs-4-5-1-for-mmpbsa/1911/3 "2021-04-11T02:51:53Z")
You can try my updated g\_mmpbsa for Windows system., which is based on gromacs 2021.1，so all lower than 2021.1 can use this tool on Windows. > **[liuyujie714/g\_mmpbsa\_windows](https://github.com/liuyujie714/g_mmpbsa_windows)** > > Unofficial g\_mmpbsa Windows version supporting the latest gromacs 2021.x