# Gromacs. One or more water molecules can not be settled during minimization

**URL:** <https://gromacs.bioexcel.eu/t/gromacs-one-or-more-water-molecules-can-not-be-settled-during-minimization/7524>\
**Category:** User discussions\
**Created:** [November 1, 2023, 10:51am UTC](https://gromacs.bioexcel.eu/t/gromacs-one-or-more-water-molecules-can-not-be-settled-during-minimization/7524 "2023-11-01T10:51:43Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Nik](https://avatars.discourse-cdn.com/v4/letter/n/6de8d8/32.png) [@Nik](https://gromacs.bioexcel.eu/u/Nik)\
**Post date:** [November 1, 2023, 10:51am UTC](https://gromacs.bioexcel.eu/t/gromacs-one-or-more-water-molecules-can-not-be-settled-during-minimization/7524/1 "2023-11-01T10:51:43Z")

</div>

GROMACS version: 2023.1  
GROMACS modification: No  
During minimization in Gromacs of the protein molecule (standard procedure for protein without any ligands) I get notification after 13th step:  
[One or more water molecules can not be settled  
Check for bad contacts and/or reduce the timestep if appropriate.  
Wrote pdb files with previous and current cordinates.]  
But then minimization continues to the 514th step when Gromacs writes lowest coordinates.  
I use standard minim.mdp file with recommended for Charmm ff parametrs and integrator = steep.  
Is it necessary to change something or it is Ok if minimization runs to its end?