# How to calculate the binding energy in the Martini coarse-grained MD simulation?
**URL:** https://gromacs.bioexcel.eu/t/how-to-calculate-the-binding-energy-in-the-martini-coarse-grained-md-simulation/328
**Category:** User discussions
**Created:** [June 17, 2020, 6:33am UTC](https://gromacs.bioexcel.eu/t/how-to-calculate-the-binding-energy-in-the-martini-coarse-grained-md-simulation/328 "2020-06-17T06:33:34Z")
**Posts on this page:** 3
**Page:** 1
### Author:  [@Tim](https://gromacs.bioexcel.eu/u/Tim)
#### Post date: [June 17, 2020, 6:33am UTC](https://gromacs.bioexcel.eu/t/how-to-calculate-the-binding-energy-in-the-martini-coarse-grained-md-simulation/328/1 "2020-06-17T06:33:34Z")
GROMACS version: 2020
GROMACS modification: No
Here post your question
Hi everyone,
I want to calculate the binding energy between the protein and the solid surface in Martini coarse-grained MD simulations conducted by Gromacs.
Could you tell me how to do that?
Many thanks, and best wishes.
Tim
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### Author:  [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)
#### Post date: [June 18, 2020, 3:23pm UTC](https://gromacs.bioexcel.eu/t/how-to-calculate-the-binding-energy-in-the-martini-coarse-grained-md-simulation/328/2 "2020-06-18T15:23:50Z")
Probably the most conventional approach would be umbrella sampling.
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### Author:  [@Tim](https://gromacs.bioexcel.eu/u/Tim)
#### Post date: [June 23, 2020, 5:49am UTC](https://gromacs.bioexcel.eu/t/how-to-calculate-the-binding-energy-in-the-martini-coarse-grained-md-simulation/328/3 "2020-06-23T05:49:07Z")
Thank you very much!