# How to use brownian dynamics with gromacs

**URL:** <https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543>\
**Category:** User discussions\
**Tags:** forcefield, mdrun, simulation-setup\
**Created:** [March 7, 2024, 5:39am UTC](https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543 "2024-03-07T05:39:14Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![Baibhabshri](https://avatars.discourse-cdn.com/v4/letter/b/e47774/32.png) [@Baibhabshri](https://gromacs.bioexcel.eu/u/Baibhabshri)\
**Post date:** [March 7, 2024, 5:39am UTC](https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543/1 "2024-03-07T05:39:14Z")

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GROMACS version:2021.4  
GROMACS modification: No  
I want to study the protein aggregation of two different protein, one is the monomer and another is a fibril having 5 chains. I want to use coarse-grained model. Is it possible to use brownian dynamics with gromacs?

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**Author:** ![Karis](https://avatars.discourse-cdn.com/v4/letter/k/ed8c4c/32.png) [@Karis](https://gromacs.bioexcel.eu/u/Karis)\
**Post date:** [March 7, 2024, 7:53am UTC](https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543/2 "2024-03-07T07:53:26Z")

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Yes, you can set the integrator to bd in the mdp file for brownian dynamics (you can find more details on setting up the mdp parameters at [https://manual.gromacs.org/documentation/2018/user-guide/mdp-options.html#run-control](https://manual.gromacs.org/documentation/2018/user-guide/mdp-options.html#run-control))

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**Author:** ![Baibhabshri](https://avatars.discourse-cdn.com/v4/letter/b/e47774/32.png) [@Baibhabshri](https://gromacs.bioexcel.eu/u/Baibhabshri)\
**Post date:** [March 12, 2024, 12:27pm UTC](https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543/3 "2024-03-12T12:27:54Z")

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thank you, I got it

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**Author:** ![paweland](https://avatars.discourse-cdn.com/v4/letter/p/278dde/32.png) [@paweland](https://gromacs.bioexcel.eu/u/paweland)\
**Post date:** [November 25, 2024, 1:53pm UTC](https://gromacs.bioexcel.eu/t/how-to-use-brownian-dynamics-with-gromacs/8543/4 "2024-11-25T13:53:20Z")

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Hi, Sir. Have You performed your BD simulation of proteins? Could You tell me please how to set mdp files and a system for BD simulation?