# How to use plumed for Steered Molecular Dynamics (SMD) in Gromacs?

**URL:** <https://gromacs.bioexcel.eu/t/how-to-use-plumed-for-steered-molecular-dynamics-smd-in-gromacs/4115>\
**Category:** User discussions\
**Created:** [May 5, 2022, 7:06am UTC](https://gromacs.bioexcel.eu/t/how-to-use-plumed-for-steered-molecular-dynamics-smd-in-gromacs/4115 "2022-05-05T07:06:28Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![Gourav](https://avatars.discourse-cdn.com/v4/letter/g/278dde/32.png) [@Gourav](https://gromacs.bioexcel.eu/u/Gourav)\
**Post date:** [May 5, 2022, 7:06am UTC](https://gromacs.bioexcel.eu/t/how-to-use-plumed-for-steered-molecular-dynamics-smd-in-gromacs/4115/1 "2022-05-05T07:06:28Z")

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GROMACS version: 2021.4 (mpi version)  
GROMACS modification: Yes/No  
Here post your question I want to perform SMD in gromacs, but as I have a large number of systems, it is not possible to perform umbrella sampling for each of these systems. Hence, I want to use Plumed for performing this SMD. How can I implement plumed into gromacs? Also I want to know what is basic difference between Umbrella sampling and SMD? As far as I know, Umbrella sampling is also a type of SMD. Let me know if I am wrong.

Thanking you in advance.