# Is there any meaningful difference between Gromacs Version 4.5.x and new version results?

**URL:** <https://gromacs.bioexcel.eu/t/is-there-any-meaningful-difference-between-gromacs-version-4-5-x-and-new-version-results/10608>\
**Category:** User discussions\
**Created:** [November 22, 2024, 8:40am UTC](https://gromacs.bioexcel.eu/t/is-there-any-meaningful-difference-between-gromacs-version-4-5-x-and-new-version-results/10608 "2024-11-22T08:40:08Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![mj.rezayani](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/mj.rezayani/32/3918_2.png) [@mj.rezayani](https://gromacs.bioexcel.eu/u/mj.rezayani)\
**Post date:** [November 22, 2024, 8:40am UTC](https://gromacs.bioexcel.eu/t/is-there-any-meaningful-difference-between-gromacs-version-4-5-x-and-new-version-results/10608/1 "2024-11-22T08:40:08Z")

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Dear GMX users,

I recently did a simulation of water diffusion into the medium. I got the parameters from an old paper (2014) using Gromacs version 4.5.x. Now, I am using Gromcas versions 2022 and 2024. Unfortunately, I can not reproduce the diffusion coefficients reported in the paper. I checked many different adjustments but I was not successful. Is it possible to be the issue of the Gromacs version?

Thanks