# Isothermal compressibility of biphasic system

**URL:** <https://gromacs.bioexcel.eu/t/isothermal-compressibility-of-biphasic-system/8999>\
**Category:** User discussions\
**Created:** [April 27, 2024, 5:51am UTC](https://gromacs.bioexcel.eu/t/isothermal-compressibility-of-biphasic-system/8999 "2024-04-27T05:51:35Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![SP06](https://avatars.discourse-cdn.com/v4/letter/s/ecb155/32.png) [@SP06](https://gromacs.bioexcel.eu/u/SP06)\
**Post date:** [April 27, 2024, 5:51am UTC](https://gromacs.bioexcel.eu/t/isothermal-compressibility-of-biphasic-system/8999/1 "2024-04-27T05:51:35Z")

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GROMACS version: 2021.4  
GROMACS modification: Yes/No  
Here post your question : Hi, I wanted to know if changing the compressibility in npt.mdp and md.mdp file is important if I am using any other solvent than water, like cyclohexane. Then how should the compressibility change if we are using a biphasic system of cyclohexane-water? (I am using charmm36 forcefield). Kindly help me with this.