# MD simulation in the solvent other than water **URL:** \ **Category:** User discussions\ **Created:** [December 20, 2021, 12:49pm UTC](https://gromacs.bioexcel.eu/t/md-simulation-in-the-solvent-other-than-water/3333 "2021-12-20T12:49:19Z")\ **Posts on this page:** 3\ **Page:** 1
**Author:** ![merry](https://avatars.discourse-cdn.com/v4/letter/m/e480ec/32.png) [@merry](https://gromacs.bioexcel.eu/u/merry)\ **Post date:** [December 20, 2021, 12:49pm UTC](https://gromacs.bioexcel.eu/t/md-simulation-in-the-solvent-other-than-water/3333/1 "2021-12-20T12:49:19Z")
GROMACS version: 2019 Dear gromacs users, Is it possible to simulate a protein in a solvent other than water with Gromacs? If so, what are the solvents and how to use them? Best, ---
**Author:** ![merry](https://avatars.discourse-cdn.com/v4/letter/m/e480ec/32.png) [@merry](https://gromacs.bioexcel.eu/u/merry)\ **Post date:** [December 20, 2021, 1:47pm UTC](https://gromacs.bioexcel.eu/t/md-simulation-in-the-solvent-other-than-water/3333/2 "2021-12-20T13:47:10Z")
I found this link in gmx website: [http://www.gromacs.org/Documentation\_of\_outdated\_versions/How-tos/Non-Water\_Solvation](http://www.gromacs.org/Documentation_of_outdated_versions/How-tos/Non-Water_Solvation) This page refers to the following link: [http://virtualchemistry.org](http://virtualchemistry.org) But I did not find the equilibrated box of non-water solvents and suitable parameters. Best, ---
**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\ **Post date:** [December 20, 2021, 3:50pm UTC](https://gromacs.bioexcel.eu/t/md-simulation-in-the-solvent-other-than-water/3333/3 "2021-12-20T15:50:44Z")
There is no repository of non-water solvent coordinates or topologies. You have to build these yourself.