# Optimization CPU time

**URL:** <https://gromacs.bioexcel.eu/t/optimization-cpu-time/9253>\
**Category:** User discussions\
**Created:** [May 29, 2024, 6:42pm UTC](https://gromacs.bioexcel.eu/t/optimization-cpu-time/9253 "2024-05-29T18:42:23Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![torquato](https://avatars.discourse-cdn.com/v4/letter/t/8baadc/32.png) [@torquato](https://gromacs.bioexcel.eu/u/torquato)\
**Post date:** [May 29, 2024, 6:42pm UTC](https://gromacs.bioexcel.eu/t/optimization-cpu-time/9253/1 "2024-05-29T18:42:23Z")

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GROMACS version:2022/2022.6  
GROMACS modification: No  
Dear all.  
I installed Gromacs on four machines, present in the UNIFESP Data Center, each machine has the following architecture:  
Architecture: x86\_64  
CPU op-mode(s): 32-bit, 64-bit  
Byte Order: Little Endian  
Address sizes: 48 bits physical, 48 bits virtual  
CPU(s): 24  
On-line CPU(s) list: 0-23  
Thread(s) per core: 2  
Core(s) per socket: 6  
Socket(s): 2  
NUMA node(s): 4  
Vendor ID: AuthenticAMD  
CPU family: 21  
Model: 2  
Model name: AMD Opteron™ Processor 6344  
Stepping: 0  
Frequency boost: enabled  
CPU MHz: 2725.556  
CPU max MHz: 2600.0000  
CPU min MHz: 1400.0000  
BogoMIPS: 5199.82  
Virtualization: AMD-V  
L1d cache: 192 KiB  
L1i cache: 768 KiB  
L2 cache: 24 MiB  
L3 cache: 24 MiB  
NUMA node0 CPU(s): 0-5  
NUMA node1 CPU(s): 6-11  
NUMA node2 CPU(s): 12-17  
NUMA node3 CPU(s): 18-23  
At the moment I am using SIMD instructions to optimize the simulation in each maquine  
My question is: Is it possible to parallelize the jobs between machines?  
If so, where can I find the instructuion for it.  
Thank’s

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**Author:** ![MagnusL](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/magnusl/32/2380_2.png) [@MagnusL](https://gromacs.bioexcel.eu/u/MagnusL)\
**Post date:** [May 30, 2024, 1:51pm UTC](https://gromacs.bioexcel.eu/t/optimization-cpu-time/9253/2 "2024-05-30T13:51:23Z")

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See if [Getting good performance from mdrun - GROMACS 2024.2 documentation](https://manual.gromacs.org/current/user-guide/mdrun-performance.html), especially [Getting good performance from mdrun - GROMACS 2024.2 documentation](https://manual.gromacs.org/current/user-guide/mdrun-performance.html#parallelization-over-multiple-nodes-via-mpi) helps you.