# Parameter file generation

**URL:** https://gromacs.bioexcel.eu/t/parameter-file-generation/6126
**Category:** User discussions
**Tags:** mdp-parameters
**Created:** [April 6, 2023, 10:20am UTC](https://gromacs.bioexcel.eu/t/parameter-file-generation/6126 "2023-04-06T10:20:46Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![Shivam30](https://avatars.discourse-cdn.com/v4/letter/s/a9adbd/32.png) [@Shivam30](https://gromacs.bioexcel.eu/u/Shivam30)
#### Post date: [April 6, 2023, 10:20am UTC](https://gromacs.bioexcel.eu/t/parameter-file-generation/6126/1 "2023-04-06T10:20:46Z")

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GROMACS version:  
GROMACS modification: Yes/No  
Is it possible to create a topology parameter files for a bigger molecules like LPS using CgenFF platform ? - " getting an error saying : readmol2 warning: atom or bond number too high; skipped molecule "

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### Author: ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)
#### Post date: [April 8, 2023, 5:59pm UTC](https://gromacs.bioexcel.eu/t/parameter-file-generation/6126/2 "2023-04-08T17:59:59Z")

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You should not attempt to generate topologies for huge molecules; this goes against force field transferability. Use small model compounds and piece the larger topology together. You will probably find that you should not even be using a general force field because everything you need for such a species is already in the parent force field.