# QM/MM tutorial for binding free energies

**URL:** <https://gromacs.bioexcel.eu/t/qm-mm-tutorial-for-binding-free-energies/813>\
**Category:** User discussions\
**Created:** [September 15, 2020, 11:17am UTC](https://gromacs.bioexcel.eu/t/qm-mm-tutorial-for-binding-free-energies/813 "2020-09-15T11:17:04Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![ganesh7shahane](https://avatars.discourse-cdn.com/v4/letter/g/51bf81/32.png) [@ganesh7shahane](https://gromacs.bioexcel.eu/u/ganesh7shahane)\
**Post date:** [September 15, 2020, 11:17am UTC](https://gromacs.bioexcel.eu/t/qm-mm-tutorial-for-binding-free-energies/813/1 "2020-09-15T11:17:04Z")

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Dear Gromacs users,

I was wondering if you are aware of any well-established tutorials/protocols that have been written/published to calculate protein-ligand binding free energies in Gromacs, where the ligand is treated quantum-mechanically and the rest of protein-water system is MM?

While there are quite a few tutorials out there, none of them seem to be specifically tailored towards calculating binding free energies.

This is something I am looking for to implement in my research.

Many thanks,  
Ganesh