# QMMM with Gaussian

**URL:** <https://gromacs.bioexcel.eu/t/qmmm-with-gaussian/3927>\
**Category:** User discussions\
**Tags:** qm-mm\
**Created:** [March 30, 2022, 12:07pm UTC](https://gromacs.bioexcel.eu/t/qmmm-with-gaussian/3927 "2022-03-30T12:07:08Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![msanocki](https://avatars.discourse-cdn.com/v4/letter/m/e36b37/32.png) [@msanocki](https://gromacs.bioexcel.eu/u/msanocki)\
**Post date:** [March 30, 2022, 12:07pm UTC](https://gromacs.bioexcel.eu/t/qmmm-with-gaussian/3927/1 "2022-03-30T12:07:08Z")

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GROMACS version: 2020

Hello,

I want to apply the QM/MM method to my system to study the mechanism of enzymatic reaction. Is it possible to use gaussian 16 with gromacs for this purpose?

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**Author:** ![dmorozov](https://avatars.discourse-cdn.com/v4/letter/d/dec6dc/32.png) [@dmorozov](https://gromacs.bioexcel.eu/u/dmorozov)\
**Post date:** [April 5, 2022, 1:41pm UTC](https://gromacs.bioexcel.eu/t/qmmm-with-gaussian/3927/2 "2022-04-05T13:41:36Z")

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Hi,

No gaussian is not supported by the modern versions of GROMACS.  
You can search for an old version, like 4.6.5 which used to have some Gaussian support.  
But they are no longer supported.