# Raising the temperature - simulation of bilayer/protein in GROMACS

**URL:** <https://gromacs.bioexcel.eu/t/raising-the-temperature-simulation-of-bilayer-protein-in-gromacs/3405>\
**Category:** User discussions\
**Created:** [January 5, 2022, 4:33pm UTC](https://gromacs.bioexcel.eu/t/raising-the-temperature-simulation-of-bilayer-protein-in-gromacs/3405 "2022-01-05T16:33:06Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![JakubH](https://avatars.discourse-cdn.com/v4/letter/j/df788c/32.png) [@JakubH](https://gromacs.bioexcel.eu/u/JakubH)\
**Post date:** [January 5, 2022, 4:33pm UTC](https://gromacs.bioexcel.eu/t/raising-the-temperature-simulation-of-bilayer-protein-in-gromacs/3405/1 "2022-01-05T16:33:06Z")

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GROMACS version: 2018.4  
GROMACS modification: No  
Hi, I have a question. [KALP-15 in DPPC](http://www.mdtutorials.com/gmx/membrane_protein/06_equil.html) When you simulate systems composed of proteins or systems composed of a membrane, do you gradually increase the temperature in GROMACS, e.g. every 10 degrees per 1 nanosecond, or maybe you give the desired temperature at once, e.g. 295 K. In the tutorials, I can see that it is immediately defined high. Is it good for the simulating system, may it have some negative effects? Or is gromacs doing it in a gradual manner and is it safe?

Thank you very much in advance for any answers

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**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\
**Post date:** [January 5, 2022, 6:36pm UTC](https://gromacs.bioexcel.eu/t/raising-the-temperature-simulation-of-bilayer-protein-in-gromacs/3405/2 "2022-01-05T18:36:56Z")

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I have never found a need to slowly warm a system. Some people swear by it, but I’d say it’s a somewhat uncommon approach these days.

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**Author:** ![JakubH](https://avatars.discourse-cdn.com/v4/letter/j/df788c/32.png) [@JakubH](https://gromacs.bioexcel.eu/u/JakubH)\
**Post date:** [January 5, 2022, 6:43pm UTC](https://gromacs.bioexcel.eu/t/raising-the-temperature-simulation-of-bilayer-protein-in-gromacs/3405/3 "2022-01-05T18:43:32Z")

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Thanks for the answer. I thought so too. I know in past research It happened twenty years ago and I heard about it, but now I don’t see anybody taking this kind of approach in scientific papers.