# REMD on GPU

**URL:** <https://gromacs.bioexcel.eu/t/remd-on-gpu/1048>\
**Category:** User discussions\
**Created:** [November 4, 2020, 7:35pm UTC](https://gromacs.bioexcel.eu/t/remd-on-gpu/1048 "2020-11-04T19:35:31Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![scinikhil](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/scinikhil/32/3483_2.png) [@scinikhil](https://gromacs.bioexcel.eu/u/scinikhil)\
**Post date:** [November 4, 2020, 7:35pm UTC](https://gromacs.bioexcel.eu/t/remd-on-gpu/1048/1 "2020-11-04T19:35:31Z")

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GROMACS version:  
GROMACS modification: Yes/No  
Here post your question Dear all,  
Is it necessary to compile GROMACS with MPI+GPU to run REMD calculation? GPU alone does work?

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**Author:** ![pszilard](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/pszilard/32/21_2.png) [@pszilard](https://gromacs.bioexcel.eu/u/pszilard)\
**Post date:** [November 5, 2020, 4:45pm UTC](https://gromacs.bioexcel.eu/t/remd-on-gpu/1048/2 "2020-11-05T16:45:04Z")

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Please see the documentation:

> **[Replica exchange — GROMACS 2020.4 documentation](http://manual.gromacs.org/documentation/current/reference-manual/algorithms/replica-exchange.html)**