# REMD reported an error

**URL:** <https://gromacs.bioexcel.eu/t/remd-reported-an-error/6199>\
**Category:** User discussions\
**Created:** [April 16, 2023, 10:25am UTC](https://gromacs.bioexcel.eu/t/remd-reported-an-error/6199 "2023-04-16T10:25:53Z")\
**Posts on this page:** 1\
**Page:** 1

<div class="post-metadata">

**Author:** ![kangwei](https://avatars.discourse-cdn.com/v4/letter/k/6bbea6/32.png) [@kangwei](https://gromacs.bioexcel.eu/u/kangwei)\
**Post date:** [April 16, 2023, 10:25am UTC](https://gromacs.bioexcel.eu/t/remd-reported-an-error/6199/1 "2023-04-16T10:25:53Z")

</div>

GROMACS version:2022.1  
GROMACS modification: No  
Here post your question When I used GROMACS for REMD simulation, I built 48 replicas, corresponding to different temperature md.mdp files generated .tpr files, but I used mpirun -np 48 gmx\_mpi mdrun -multidir md\* -replex 1000 -deffnm md -ntomp 1 when submitting a computing task to the server, the following error appeared, what is the reason ？

Program: gmx mdrun, version 2022.1  
Source file: src/gromacs/utility/futil.cpp (line 470)  
MPI rank: 41 (out of 48)

File input/output error:  
md.tpr

For more information and tips for troubleshooting, please check the GROMACS  
website at [Common Errors — GROMACS webpage https://www.gromacs.org documentation](http://www.gromacs.org/Documentation/Errors)