# Replica Exchange: Mdrun parameters

**URL:** <https://gromacs.bioexcel.eu/t/replica-exchange-mdrun-parameters/922>\
**Category:** User discussions\
**Created:** [October 6, 2020, 11:38pm UTC](https://gromacs.bioexcel.eu/t/replica-exchange-mdrun-parameters/922 "2020-10-06T23:38:51Z")\
**Posts on this page:** 1\
**Showing post:** 2

<div class="post-metadata">

**Author:** ![alevilla](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/alevilla/32/439_2.png) [@alevilla](https://gromacs.bioexcel.eu/u/alevilla)\
**Post date:** [October 12, 2020, 8:41am UTC](https://gromacs.bioexcel.eu/t/replica-exchange-mdrun-parameters/922/2 "2020-10-12T08:41:43Z")

</div>

Hi,  
here a post that can be useful

> [@Unable to run REMD simulation](https://gromacs.bioexcel.eu/t/unable-to-run-remd-simulation/237):
>
> GROMACS version: 2019.5 GROMACS modification: No Dear users, I am trying to run a REMD simulation, with the replica files in the working directory having names like testrun\_1.tpr, testrun\_2.tpr, etc. However, upon running the command below with SLURM architecture: mpirun gmx\_mpi mdrun -s testrun\_.tpr -v -deffnm testrun\_ -replex 500 \>\> replex\_1.log I get errors like: Error in user input: Invalid command-line options In command-line option -s File ‘testrun\_.tpr’ (or ‘testrun\_’) does not …

Best regards  
Alessandra

---

_[View the full topic](https://gromacs.bioexcel.eu/t/replica-exchange-mdrun-parameters/922)._