# REST2 implementation in 2018.3 version

**URL:** <https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407>\
**Category:** User discussions\
**Created:** [July 1, 2020, 4:49am UTC](https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407 "2020-07-01T04:49:23Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![zmazhar](https://avatars.discourse-cdn.com/v4/letter/z/6bbea6/32.png) [@zmazhar](https://gromacs.bioexcel.eu/u/zmazhar)\
**Post date:** [July 1, 2020, 4:49am UTC](https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407/1 "2020-07-01T04:49:23Z")

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GROMACS version: 2018.3  
GROMACS modification: Yes/No  
Here post your question Does this version require modifications to the Forcefield for REST2 simulation?

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**Author:** ![Dr\_DBW](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/dr_dbw/32/42_2.png) [@Dr\_DBW](https://gromacs.bioexcel.eu/u/Dr_DBW)\
**Post date:** [July 1, 2020, 10:27pm UTC](https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407/2 "2020-07-01T22:27:33Z")

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No, you use which ever FF you are using as it is, it is just a replica exchange method.

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**Author:** ![zmazhar](https://avatars.discourse-cdn.com/v4/letter/z/6bbea6/32.png) [@zmazhar](https://gromacs.bioexcel.eu/u/zmazhar)\
**Post date:** [July 2, 2020, 12:05am UTC](https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407/3 "2020-07-02T00:05:43Z")

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Thank you for your help!!

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**Author:** ![siddiqh](https://avatars.discourse-cdn.com/v4/letter/s/ecccb3/32.png) [@siddiqh](https://gromacs.bioexcel.eu/u/siddiqh)\
**Post date:** [July 11, 2020, 2:02pm UTC](https://gromacs.bioexcel.eu/t/rest2-implementation-in-2018-3-version/407/4 "2020-07-11T14:02:23Z")

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Hi,  
Is REST2 and Hamiltonian replica exchange are same?  
is it implemented in gromacs version 2020?, and if I want to run Hamiltonian replica exchange only using gromacs without plumed is it possible?

Thanks