# Solvating other than water

**URL:** <https://gromacs.bioexcel.eu/t/solvating-other-than-water/8765>\
**Category:** User discussions\
**Created:** [April 2, 2024, 5:53am UTC](https://gromacs.bioexcel.eu/t/solvating-other-than-water/8765 "2024-04-02T05:53:15Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![alexmathew](https://avatars.discourse-cdn.com/v4/letter/a/f4b2a3/32.png) [@alexmathew](https://gromacs.bioexcel.eu/u/alexmathew)\
**Post date:** [April 2, 2024, 5:53am UTC](https://gromacs.bioexcel.eu/t/solvating-other-than-water/8765/1 "2024-04-02T05:53:15Z")

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GROMACS version:2023  
GROMACS modification: Yes/No  
Here post your question  
Hi everyone,  
I need to solvate a system with non-water, which i have gro file, do i need to remove the solvent.gro box information? i found that when i remove the box inforamtion it adds more number of sovlent molecule for a a particular box.

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**Author:** ![MichelePellegrino](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/michelepellegrino/32/628_2.png) [@MichelePellegrino](https://gromacs.bioexcel.eu/u/MichelePellegrino)\
**Post date:** [April 2, 2024, 6:17am UTC](https://gromacs.bioexcel.eu/t/solvating-other-than-water/8765/2 "2024-04-02T06:17:18Z")

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Hi alexmathew,  
What do you mean by ‘box information’? You mean the box dimensions (last line)?  
What has worked consistently for me is to give a box that has been equilibrated at the target temperature and pressure to `-cs`. I believe that if you start from a single molecule (which may be your case?), `gmx solvate` doesn’t really work, since it tries to tile the input box. That may also explain why changing the box dimensions tunes the amount of solvent molecules.