# Solvent distribution

**URL:** <https://gromacs.bioexcel.eu/t/solvent-distribution/2299>\
**Category:** User discussions\
**Created:** [June 5, 2021, 2:03pm UTC](https://gromacs.bioexcel.eu/t/solvent-distribution/2299 "2021-06-05T14:03:53Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![MOH4](https://avatars.discourse-cdn.com/v4/letter/m/a87d85/32.png) [@MOH4](https://gromacs.bioexcel.eu/u/MOH4)\
**Post date:** [June 5, 2021, 2:03pm UTC](https://gromacs.bioexcel.eu/t/solvent-distribution/2299/1 "2021-06-05T14:03:53Z")

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Dear all,

Could you please tell me by which command the distribution of solvent molecules (%) around protein based on distance can be calculated?  
Solvent (%) per distance from protein (nm).

Many thanks for your response.  
Best.

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**Author:** ![Teslim](https://avatars.discourse-cdn.com/v4/letter/t/f1d935/32.png) [@Teslim](https://gromacs.bioexcel.eu/u/Teslim)\
**Post date:** [June 5, 2021, 8:31pm UTC](https://gromacs.bioexcel.eu/t/solvent-distribution/2299/2 "2021-06-05T20:31:29Z")

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Check gmx sasa

[https://manual.gromacs.org/documentation/5.1/onlinehelp/gmx-sasa.html](https://manual.gromacs.org/documentation/5.1/onlinehelp/gmx-sasa.html)

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**Author:** ![jalemkul](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/jalemkul/32/18_2.png) [@jalemkul](https://gromacs.bioexcel.eu/u/jalemkul)\
**Post date:** [June 10, 2021, 1:26pm UTC](https://gromacs.bioexcel.eu/t/solvent-distribution/2299/3 "2021-06-10T13:26:51Z")

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Computing radial distribution functions and coordination numbers would be more useful here than SASA. The RDF specifically calculates the enrichment of a given species at a range of distances relative to bulk solution.