# Umbrella sampling problem

**URL:** <https://gromacs.bioexcel.eu/t/umbrella-sampling-problem/5007>\
**Category:** User discussions\
**Created:** [October 13, 2022, 5:57am UTC](https://gromacs.bioexcel.eu/t/umbrella-sampling-problem/5007 "2022-10-13T05:57:46Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Pallavi](https://avatars.discourse-cdn.com/v4/letter/p/3be4f8/32.png) [@Pallavi](https://gromacs.bioexcel.eu/u/Pallavi)\
**Post date:** [October 13, 2022, 5:57am UTC](https://gromacs.bioexcel.eu/t/umbrella-sampling-problem/5007/1 "2022-10-13T05:57:47Z")

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GROMACS version:  
GROMACS modification: Yes/No  
Here post your question i have to do umbrella sampling. I have done dna ligand md simulation , i want to know from where i started to use complexes as the justin tutorial use onlly protein molecule i want to use form my complex.

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**Author:** ![cathrine](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/cathrine/32/1736_2.png) [@cathrine](https://gromacs.bioexcel.eu/u/cathrine)\
**Post date:** [October 14, 2022, 1:39pm UTC](https://gromacs.bioexcel.eu/t/umbrella-sampling-problem/5007/2 "2022-10-14T13:39:41Z")

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Dear Pallavi,  
Here’s an answer to a similar question: [Umbrella Sampling for Protein-Ligand Complexes](https://gromacs.bioexcel.eu/t/umbrella-sampling-for-protein-ligand-complexes/2234)