# What is the typical MD calculation time? **URL:** \ **Category:** User discussions\ **Created:** [March 8, 2024, 5:35pm UTC](https://gromacs.bioexcel.eu/t/what-is-the-typical-md-calculation-time/8558 "2024-03-08T17:35:00Z")\ **Posts on this page:** 3\ **Page:** 1
**Author:** ![Roger](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/roger/32/1992_2.png) [@Roger](https://gromacs.bioexcel.eu/u/Roger)\ **Post date:** [March 8, 2024, 5:35pm UTC](https://gromacs.bioexcel.eu/t/what-is-the-typical-md-calculation-time/8558/1 "2024-03-08T17:35:00Z")
GROMACS version: 2023.3 GROMACS modification: No Here post your question We have a molecular system of : 1 ligand (67 atoms) + 1 protein (537 atoms) + appoximately 25000 water molecules (75000 atoms). Since we interested in molecular dynamic interactions/binding energy and secondary structures, and considering that it depends of many parameters, what would be a typical minimal or approximate average calculation times to get reliable results (in microseconds)? Thanks ---
**Author:** ![scinikhil](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/scinikhil/32/3483_2.png) [@scinikhil](https://gromacs.bioexcel.eu/u/scinikhil)\ **Post date:** [March 8, 2024, 6:14pm UTC](https://gromacs.bioexcel.eu/t/what-is-the-typical-md-calculation-time/8558/2 "2024-03-08T18:14:56Z")
There is no such standard time for this. There are pubications from 100 ns to more than microsecond, depends on your protein/receptor and what you are looking for., also your computational fascility. I would start with atleast 500 ns or 1 microsecond, if i have enough computational or multiple simulations with different initial velocity/position. ---
**Author:** ![Roger](https://dub1.discourse-cdn.com/flex017/user_avatar/gromacs.bioexcel.eu/roger/32/1992_2.png) [@Roger](https://gromacs.bioexcel.eu/u/Roger)\ **Post date:** [March 8, 2024, 6:36pm UTC](https://gromacs.bioexcel.eu/t/what-is-the-typical-md-calculation-time/8558/3 "2024-03-08T18:36:28Z")
Thanks Scinikhil, for the quick reply ; I will run with 1 or more microseconds! Regards