When simulate ball -shaped or 2D bubbles, you should choose NPT or NVT?Is NPT right?

Excuse me, if you do air bubbles, can you not NPT, because Laplas pressure, different pressure inside and outside the bubbles, cannot control a pressure. What if you use NPT?
If you use NVT, can GMX simulate the pressure of Laplas and then make the pressure inside the bubble greater than the liquid pressure?
This also involves how to choose the number of bubble molecules. After finding the article, there is no answer. You comrades have known for help. Thank you very much!