High Penalty score in ligand topology

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GROMACS version:
GROMACS modification: Yes/No
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How can i fix it if i have high penalty scores while generating a ligand topology from cgenff server? How much of the penalty score can be tolerated? What does it mean to have a large penalty score?

2

The CGenFF paper deals with this directly and comments in the topology the server produces tells you what the ranges of penalty scores mean.

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