Umbrella Sampling for Protein-Ligand Complexes

I would like to perform umbrella sampling for protein-ligand complexes. The ligand is a small organic compound, i.e. cryptamygin-A. Which is the best force field to use? Are there any helpful articles, reviews, papers or tutorials for such projects?

Thanks in advance

The “best” force field is the one for which you can easily and accurately parametrize the ligand.

Articles abound for these kinds of calculations. The umbrella sampling tutorial I wrote (Umbrella Sampling) can easily be adapted for your case, you just don’t pull along a single Cartesian axis, you define a sensible reaction coordinate between the ligand and its binding site and the bias should likely be applied in all three dimensions.

Thank you for the quick response