Error: 2 particles communicated to PME rank 3

GROMACS version:
GROMACS modification: Yes/No
2 particles communicated to PME rank 3 are more than 2/3 times the cut-off out
of the domain decomposition cell of their charge group in dimension x.
This usually means that your system is not well equilibrated.

Hi,
maybe you can provide more information and formulate which is exactly your questions. That makes easy for others to help you.
Best regards
Alessandra