File input/output error

GROMACS version: 5.1.4
I simulated a system of RBMX protein in 0.1mol/L NaCl on the cluster of my department, with 2000ns simulation time, 1000000000 steps. After 5 days the job stopped and the output file reads:
File input/output error :

What is the reason of this error? And how to deal with it?

Thanks for your help!

This sounds like an issue with your cluster, possibly the cluster filesystem has an issue or there is a connection issue on the cluster. If something like this happens, it’s also useful to run gmx check -f [yourtrajectory] to make sure that your trajectory is still okay.

Thanks a lot! Indeed there is an error in my trajectory.