Novice to simulate antibody-drug-conjugate -- unnatural residues

GROMACS version: 2022
GROMACS modification: No
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Hi, friends in this Gromacs forum:

I am a novice in gromacs, but I can finish MD of glycoproteins using charmmGUI (which is highly novice-friendly). Now I have a big challenge with antibody-drug-conjugate (ADC) MD simulations.

As the starting point, I know I have to add unnatural residues into the force filed file. Is somewhere I can see a step-by-step guidance for adding unnatural residues into the force field?

Many thanks in advance.

from Reece

Hi,
here you find

\Alessandra