Tip3p.gro download

User discussions
1

GROMACS version:2025
GROMACS modification: no
Can someone provide me with the tip3p.gro file for this water model and the itp file as well.
Thanks in advance

2

You can find gro/itp files for different water models where you installed GROMACS, just go into the local directory where_you_installed_gromacs/share/gromacs/top/.

3

Thanks so much. I found the tip3p.itp file, but not the corresponding gro file. However, I found gro files for other water models. Can I solvate the system using a different water model and still include the tip3p.itp in the topology file?

4

Hi,
you can use the “spc216.gro” file (default option in gmx solvate) to solvate your system.
Best,
Marius

5

Thank you so much for your reply. I am using the AMBER ff19SB force field, which is compatible with the OPC or TIP3P water models. My protein is a 767-residue trimer, and when I tried to solvate it using tleap, I encountered many issues. Therefore, I decided to perform the solvation step using GROMACS instead. That why I need the TIP3P specifically.