Continuation simulation in different GROMACS version

GROMACS version: 2018.4 and 2018.2
GROMACS modification: No
I have a question is it possible to continue simulation in different gromacs versions? I know that this is impossible for very old and new version together. For example I start with GROMACS 5.0.3 and then I want to continue with 2018.2. I know that this is impossible, but what about GROMACS 2018.4 and for example GROMACS 2018,2. Or 2020.2 and 2020.4 etc.? Is it possible and ok?

You can always continue an old run with a newer version, but not the other way around. I’d say it’s a really bad idea from a scientific continuity/integrity perspective, especially with such a massive jump in versions.

As noted above, you can’t go backwards.

This you could do, and would probably be OK since you’re only differing in patch release versions. I would never split a simulation between major versions, and if I was a reviewer of such a paper, I would have a big problem with that, as well.

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Thank you so much @jalemkul.