Md simulation on different gromacs version

GROMACS version:2018.3/2020.4
Dear all,
Will running a simulation on version 2018.3 and version 2020.4 can cause entirely different results?and is it advisable to run a simulation on 2020.4 version and do the analysis using 2018.3 version?if not,what will be the probable reason?

Any comments will be highly appreciated.

Thank you

You would have to go through all the release notes to see what, if any, bugs or feature changes might be relevant, and then hope there is nothing undiscovered that is different between the versions that will affect your results.

Pick a version and stick with it. This is important for scientific reproducibility.

Thank you for your suggestion.