Pressure scaling more than 1%. This may mean your system is not yet equilibrated

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I opened an issue, with high priority: Too large nstpcouple value for Parrinello-Rahman barostat increases volume fluctuations (#5424) · Issues · GROMACS / GROMACS · GitLab

I did tests for the worst case: a small water box. I uploading a fix for the release 2025 branch. This gives nstpcouple=10 with tau_p=5.

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