Raising the temperature - simulation of bilayer/protein in GROMACS

GROMACS version: 2018.4
GROMACS modification: No
Hi, I have a question. KALP-15 in DPPC When you simulate systems composed of proteins or systems composed of a membrane, do you gradually increase the temperature in GROMACS, e.g. every 10 degrees per 1 nanosecond, or maybe you give the desired temperature at once, e.g. 295 K. In the tutorials, I can see that it is immediately defined high. Is it good for the simulating system, may it have some negative effects? Or is gromacs doing it in a gradual manner and is it safe?

Thank you very much in advance for any answers

I have never found a need to slowly warm a system. Some people swear by it, but I’d say it’s a somewhat uncommon approach these days.


Thanks for the answer. I thought so too. I know in past research It happened twenty years ago and I heard about it, but now I don’t see anybody taking this kind of approach in scientific papers.