Error in user input:
Invalid input values
In option s
Required option was not provided, and the default file ‘topol’ does not
exist or is not accessible.
The following extensions were tried to complete the file name:
.tpr
You need a tpr input file, created by gmx grompp, to run gmx mdrun. The tpr file name is specified using the -s option.
Read https://manual.gromacs.org/current/user-guide/getting-started.html for more info.